Xiaohuang: DOORM, what is Anfinsen’s dogma, and what is its contribution to protein folding research?
DOORM: Anfinsen’s dogma, proposed by scientist Christian Anfinsen in 1973, states that a protein’s natural folded structure is determined solely by its amino acid sequence. This principle suggests that proteins will automatically fold into their functional three-dimensional structures under natural conditions, independent of external factors. Anfinsen’s dogma provides a theoretical foundation for protein structure prediction, advancing the fields of biochemistry and molecular biology.
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